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Kinetic Invesitigation of Substitution

Page history last edited by jbfriesen 12 years, 8 months ago

Summary of Procedure:

"The Kinetic Investigation of Substitution" is a good lab to do during the nucleophilic substitution chapter.
Student Handout Kinetics 2010

Student Handout Kinetics_2008

Positive aspects of this experiment:

+ It is a departure from the usual synthesis experiments that populate most sophomore organic chemistry laboratory calendars.

+ The use of data collection, comparison, and analysis is particularly instructive.

Neutral (may be positive or negative) aspects of this experiment:

± I have always posted "class data" for this experiment that the students may use in their laboratory report.

Negative aspects of this experiment:

- This experiment requires very good liquid measurement skills. It is practically impossible to do this lab with any consistency using volumetric glass pipettes.

- It is very sensitive and the student data is often very scattered (imprecise).

Inquiry & Extension Ideas:

● You can use a similar procedure to determine whether the reaction proceeds with an SN1 or SN2 mechanism.

● With other forms of volume measurements (syringes and/or automatic pipettes) the reproducibility of the data could be greatly enhanced (I think).

Data Links:

2010 kinetic data.xls

2008_kinetic_data.xls

2007_kinetic_data